The Science of Testicular Cooling
- healthy sperm formation is extremely sensitive to testicular overheat
- daily overheat by just 2 deg. causes sperm count and sperm motility to plummet by over 90%
- overheat can be caused by sitting/driving for longer than 20 minutes, obesity, varicocele, and hot environments
- overheat may cause permanent, abnormal changes to DNA gene expression in offspring via epigenetic pathways, leading to disease or other complications
- The Underdog prevents testicular overheat when sitting
Why Sperm Count Matters
Scientific research establishes that a higher sperm count correlates with increased fertility. As sperm counts in men rise from zero to 40 million/ml, there is a progressive increase in the chances of their partner becoming pregnant .
For example, in a study of 430 couples trying to conceive over a 6-month study period, the conception rate was 36% for men with less than 20 million/ml, and 65% for men with greater than 20 million/ml .
And evidence suggests  that better sperm morphology (a measure of quality) leads to improved fertility.
Sperm Counts in Decline
Researchers have recently confirmed an alarming trend: western male sperm count has dropped by 50-60% over the last 40 years with no signs of leveling-off. This is detailed in a recent 2017 meta-study  by Levine et al that caught the attention of world media, where researchers analyzed 183 sperm count data sets collected over the last 40 years from men in America, Europe, Australia and New Zealand.
Fig. 1: Western Sperm Count Down 50% 
While the root causes are still under investigation, overheating remains a prime suspect. During the same 40 year span our modern lifestyles have changed to more sedentary office jobs, increased commuting time, and increased screen time - all of which involve more sitting (and therefore scrotal heating) than ever before . And our steady rise in body fat percentage over this same period  is another factor adding to scrotal heating and reduced sperm count .
Heat: A Prime Suspect
The testicular tissues are exquisitely sensitive to even mild overheat. Numerous studies have shown that a small temperature rise in human scrotal temperature leads to dramatic depression of total sperm count and sperm motility, and a degradation in the quality (morphology) of the remaining sperm.
Robinson & Rock  exposed a group of 10 healthy men to a 0.8 deg. C scrotal temperature rise for 15 hours per day. This lead to an 80% reduction in sperm count in the 2-3 month time period following such exposure.
Mieusset et al [9, 10] exposed a group of 14 healthy men with normal 34 deg. C scrotums to a 2 deg. C temperature rise for 15 hours per day. This lead to a 90% reduction in sperm count and sperm motility, and a 35% reduction in normal sperm morphology of the few sperm that remained. These effects all but disappeared 3-4 months after stopping the temperature rise.
Fig. 2: Detrimental Effects of 2 deg. C Rise on Sperm Count, Motility, and Morphology [9,10]
Hjollund et al  took temperature measurements and sperm samples among 101 test subjects, and found a negative correlation whereby sperm concentration decreased 40% per 1 deg. C. increment of median daytime scrotal temperature.
Another study by Hjollund  measured median sperm concentration in a group of 66 men. Men with higher scrotal temperatures (above 35 deg. C for more than 75% of daytime) had at the median a 64% lower sperm concentration than men with lower scrotal temperatures (below 35 deg. C for at least 50% of the day).
Heat from Sitting and Driving
When sitting, the scrotum’s natural surface-area based cooling mechanisms are defeated, and the testicles rapidly heat up to a temperature where normal sperm formation cannot occur.
Jung et al  tested a group of 8 healthy men in various postures. During 1 hour phases of sitting at a writing desk or in a car, temperatures increased 2 deg. C to around the dangerous 36 deg. C mark. In contrast, values were in a safer region below 35 deg. C during a walking phase.
Fig. 3: Scrotal Heating from Sitting and Driving vs Walking 
Jung et al  tested a larger group of 50 healthy men in sitting vs walking posture. After 20 minutes of sitting, subjects experienced an average 2 deg. C scrotal temperature rise.
Bengoudifa & Mieusset  measured a group of 8 fertile volunteers and established that wearing clothing in a seated position was responsible for a 1.5 to 2 deg. C temperature rise as compared to a more natural standing position.
Bujan et al  found in a group of 9 healthy men that walking clothed outdoors resulted in a healthy mean 34.2 deg. C scrotal temperature, but driving a car caused a spike in scrotal temperature by 1.7 to 2.2 deg. C.
Fig. 4: Scrotal Heating from Driving 
Hot work environments are another risk factor for scrotal overheating.
Bonde  studied a group of 17 men exposed to hot temperatures for 5 hours per day in the course of their welding occupation, and found an average 1.4 deg. C groin temperature rise. After six weeks of exposure to this regimen, the proportion of sperm with normal shape declined significantly. This was reversible after a break in exposure.
Thonneau et al  conducted a meta-analysis of previous research reports, and concluded that occupational heat exposure (e.g. from jobs in hot environments) is a significant risk factor for male infertility, affecting sperm morphology and resulting in delayed conception.
Heat from Varicocele and Obesity
Varicocele is a condition of varicose veins in the scrotum. It affects 15% of the male population (including an Underdog founder!), and has a high correlation with male infertility - up to 35% of males with infertility have varicocele . Scrotal overheating from increased blood-flow is the most likely mechanism whereby Varicocele reduces male fertility .
Obesity is another factor associated with reduced fertility. BMI of more than 25 is associated with an average 25% reduction in sperm count and sperm motility . Higher levels of fatty tissue in the inner thigh and scrotal region are suspected of affecting scrotal cooling mechanisms and thereby increasing testicular temperatures    .
Garolla et al  monitored scrotal temperatures over a period of 2 years in a group of 80 men, 60 of which had risk factors for testicular heating such as varicocele or obesity. It was found that men with either varicocele or obesity showed higher scrotal temperatures, and these higher temperatures were related to a significant negative alteration of spermatogenesis.
Heat-Stress Induced DNA and Epigenetic Changes in Children
Inheritance of DNA-determined traits is not as simple as once thought. Epigenetic mechanisms involve DNA and histone modifications and result in the heritable silencing of genes without a change in their coding sequence. Disruption of the balance of epigenetic networks may cause several major pathologies, including cancer, syndromes involving chromosomal instabilities, and mental retardation.
New research into paternal factors      suggest that environmental factors such as heat stress on the father's body impact the offspring's inherited traits via epigenetic mechanisms, potentially causing lasting negative outcomes in offspring.
To reduce the chances of this, it is important to ensure sperm formation is optimized through reduction of risk factors in the father such as testicular overheat.
What Can We Conclude?
- Optimal sperm formation occurs a full 3 degrees Celsius (5.5 deg. F) below body temperature.
- Healthy sperm formation is extremely sensitive to heat.
- A 1 deg. C rise in scrotal temperature reduces count by 40%
- A 2 deg. C rise reduces sperm count and motility to nearly zero, and significantly impacts morphology.
- Heat stressed sperm produce changes in DNA and gene expression in offspring
- Risk factors for overheat include sitting, driving, obesity, varicocele, and hot environments.
Enter The Underdog
The Underdog has been experimentally shown to reduce the rise in scrotal temperature by 2 to 3 deg. C when clothed and seated, to keep the scrotum mean temperature in the optimal 33-34 deg. C range where sperm formation is optimized.
And most importantly, The Underdog is engineered to be safe. The non-invasive design presents no risk or discomfort to the genitals. And the level of cooling is gentle, well-controlled, and consistent, unlike a competitor’s underwear-based solution that provides a too-extreme level of cooling.
The Underdog helps your little guys reach their true potential using its patented safe, gentle method of cooling.
Sperm Count Testing
Sperm Motility Testing
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